Downstream Process Scientist
ICDS Recruitment
Offaly
Downstream Process Scientist - County Offaly. Our client is looking for the ideal candidate to develop and validate the processes for recombinant antibodies for veterinary use. This will include working with teams both in the company and externally with Contract Manufacturing Organisations for some of the process development activity and also for technical transfer of the process into the facility in Offaly. Key Responsibilities: To support the development, optimisation, scale-up and validation of all steps in the monoclonal antibody downstream processes . Work with external partners to provide the necessary technical support for successful completion of projects including process transfer. Support the writing of Batch Manufacturing Records, SOPs, and other quality system documentation required for GMP manufacture. Provide hands-on technical support for all manufacturing activities including buffer / media preparation, cell culture and purification processes. Provide technical input and support writing of technical reports required for regulatory purposes. Participate in Quality and Safety regulatory audits. Identify continuous improvement initiatives and action plans to implement operational excellence and lean practices. Carry out manufacturing as per Batch Records. Filter integrity testing and virus clearance steps in the downstream process. Qualifications and Experience sought: M.S. in Chemical/Biochemical Engineering or related Biological Sciences with at least 2 years' industrial experience or B.S in Chemical/Biochemical Engineering or related Biological Sciences with at least 5 years' industrial experience. Previous hands-on experience running chromatography systems is required. Experience developing and scaling up of downstream processes is preferred. Protein purification , lab-scale and pilot scale. Skills chromatography and filtration systems. Knowledge of analytical methods required for protein characterisation. Knowledge of key suppliers of process materials and equipment including disposable systems. Experience working with external contractors. Excellent project management capability. Preferred Qualifications: Knowledge and understanding of the workings of protein purification techniques using Unicorn software. Understanding of process characterisation and ability to write risk assessments and technical documents. This job originally appeared on RecruitIreland.com.
2291 days ago